DNA-based molecular architecture with spatially localized components

Richard A. Muscat, Karin Strauss, Luis Ceze, Georg Seelig
<span title="2013-07-26">2013</span> <i title="Association for Computing Machinery (ACM)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/35q3ync5nbhnjfpylznlz57lyi" style="color: black;">SIGARCH Computer Architecture News</a> </i> &nbsp;
Performing computation inside living cells offers life-changing applications, from improved medical diagnostics to better cancer therapy to intelligent drugs. Due to its bio-compatibility and ease of engineering, one promising approach for performing in-vivo computation is DNA strand displacement. This paper introduces computer architects to DNA strand displacement "circuits", discusses associated architectural challenges, and proposes a new organization that provides practical composability.
more &raquo; ... particular, prior approaches rely mostly on stochastic interaction of freely diffusing components. This paper proposes practical spatial isolation of components, leading to more easily designed DNA-based circuits. DNA nanotechnology is currently at a turning point, with many proposed applications being realized [20, 9] . We believe that it is time for the computer architecture community to take notice and contribute.
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