Does rosmarinic acid underestimate as an experimental cardiovascular drug?

Luciana Garros Ferreira, Andrea Carla Celotto, Verena Kise Capellini, Agnes Afrodite Sumarelli Albuquerque, Tales Rubens de Nadai, Marco Tulio Menezes de Carvalho, Paulo Roberto Barbosa Evora
2013 Acta Cirurgica Brasileira  
PURPOSE: The rationale of the present review is to analize the activity of Rosmarinus officinalis in the the cardiovascular system METHODS: A MEDLINE database search (from January 1970 to December 2011) using only rosmarinic acid as searched term. RESULTS: The references search revealed 509 references about rosmarinic acid in 40 years (the first reference is from 1970). There is a powerful prevalence of antioxidant and cancer studies. Other diseases are few cited, as inflammation, brain
more » ... tion, brain (Alzheimer and Parkinson disease) and, memory; allergy; diabetes; atherosclerosis, and; hypertension. It is necessary to consider the complete absence of studies on coronary artery disease, myocardial ischemia, heart failure or ischemia/reperfusion injury. CONCLUSION: Rosmarinic acid is underestimated as an experimental cardiovascular drug and deserves more attention.
doi:10.1590/s0102-86502013001300016 pmid:23381830 fatcat:f7x2h66iazg4lnofx5izrwuhwm