The Role of Non-Structural Protein NSs in the Pathogenesis of Severe Fever with Thrombocytopenia Syndrome

Jumana Khalil, Hiroki Kato, Takashi Fujita
2021 Viruses  
Viral non-structural proteins, such as NSs of the newly emerging severe fever with thrombocytopenia syndrome virus, are well established virulence factors, mediating viral pathogenesis and disease progression through various mechanisms. NSs has been described as a potent interferon antagonist and NF-κB agonist, two divergent signaling pathways in many immune responses upon a viral encounter. In this review, we highlight the many mechanisms used by NSs on the host that promote viral replication
more » ... viral replication and hyper-inflammation. Understanding these host-pathogen interactions is crucial for antiviral therapy development.
doi:10.3390/v13050876 pmid:34064604 fatcat:a3lgjfdourevfmt33r5wu4co3u