SYNTHESIS AND CHARACTERIZATION OF NEW HETEROCYCLIC COMPOUNDS WITH POTENTIAL ANTITUBERCULOSIS ACTIVITY AND THEIR IMMOBILIZATION ON POLYMER SUPPORTS

Radita Aparaschivei, Mihaela Holban, Valeriu Sunel, Marcel Popa, Jacques Desbrieres
2012 CELLULOSE CHEMISTRY AND TECHNOLOGY Cellulose Chem. Technol   unpublished
New biologically active compounds, obtained by synthesizing new hydrazides derived from benzoxazolyl-2-mercaptoformic acid, respectively benzoxazolyl-2-mercaptoacetic acid, have been chemically immobilized onto poly(maleic anhydride-alt-vinyl acetate) supports, forming drug-polymer conjugates with controlled delivery. The reaction products were characterized by elemental and spectral analyses (FT-IR, 1 H-NMR). Toxicological and tuberculostatic activity tests recommend certain reaction products
more » ... s therapeutic candidates with pharmacological application.
fatcat:km5ieynu6fbptl4cs6fa26xotm