We present an overview of recent efforts to calculate the interactions among hadrons using lattice QCD. After outlining the techniques that are used to extract scattering parameters, we detail the latest calculations of meson-meson scattering, baryon-baryon scattering and multi-meson systems obtained with domain-wall valence quarks on the staggered MILC lattices by the NPLQCD collaboration. Estimates of the computational resources required to achieve precision results in the baryon sector are presented.