Antinociceptive Effects of Hochu-ekki-to, Yoku-kan-san and Saiko-ka-ryukotsu-borei-to in Mice

Ai Kansaku, Takao Imai, Ichiro Takahashi, Shigeki Sawada, Michiko Yamauchi, Emi Hasegawa, Mitsutoshi Isogawa, Naruto Yoneshige
1997 Japanese Journal of Psychosomatic Dentistry  
Antinociceptive effects of the traditional Chinese (Kampo) medicines, Hochu-ekki-to, Yoku-kan-san and Saiko-ka-ryukotsu-borei-to, were studied on acetic acid-induced writhing in mice. The number of writhings observed was counted in consecutive 5 min periods for 60 min after intraperitoneal injection of 0.6% acetic acid. Kampo medicines were administered for 14 consecutive days, prior to testing, in the drinking water. Oral administration of Hochu-ekki-to (60,150 and 300 mg/kg/day)
more » ... ly reduced the number of acetic acid-induced writhings. Yoku-kan-san (60, 150 and 300mg/kg/day) tended to inhibit the writhing response to acetic acid in a dose-related manner. Saiko-ka-ryukotsu-borei-to (60, 150 and 300 mg/kg/day) markedly reduced the number of acetic acid-induced writhings but its effects were not dose-dependent. These results suggest that these Kampo medicines may have antinociceptive properties.
doi:10.11268/jjpsd1986.12.37 fatcat:wpapmi426vavpexum5xrxg2s34