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Short-term oral α-lipoic acid does not prevent lipid-induced dysregulation of glucose homeostasis in obese and overweight nondiabetic men
American Journal of Physiology. Endocrinology and Metabolism
Xiao C, Giacca A, Lewis GF. Short-term oral ␣-lipoic acid does not prevent lipid-induced dysregulation of glucose homeostasis in obese and overweight nondiabetic men. Prolonged elevation of plasma free fatty acids (FFAs) induces insulin resistance and impairs pancreatic ␤-cell adaptation to insulin resistance. The mechanisms whereby lipid induces these impairments are not fully defined but may involve oxidative stress, inflammation, and endoplasmic reticulum stress. ␣-Lipoic acid (ALA), adoi:10.1152/ajpendo.00183.2011 pmid:21750266 fatcat:xy5wdhliubgbziwlop7wtjalby