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In this report, we present features of the neuronal SNARE complex determined by atomistic molecular dynamics simulations. The results are robust for three models, varying force fields (AMBER and GROMOS) and solvent environment (explicit and implicit). An excellent agreement with experimental findings is observed. The SNARE core complex behaves like a stiff rod, with limited conformational dynamics. An accurate picture of the interactions within the complex emerges with a characteristic patterndoi:10.1529/biophysj.107.123117 pmid:18212009 pmcid:PMC2292394 fatcat:6srkm2xnpnax3cbh4qsuwbnkjq