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Increased APOEϵ4 expression is associated with reactive A1 astrocytes and the difference in Alzheimer Disease risk from diverse ancestral backgrounds [article]

Anthony J Griswold, Katrina Celis, Parker Bussies, Farid Rajabli, Patrice Whitehead, Kara Hamilton-Nelson, Gary W Beecham, Derek M Dykxhoorn, Karen Nuytemans, Liyong Wang, Olivia K Gardner, Daniel Dorfsman (+12 others)
2020 bioRxiv   pre-print

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https://web.archive.org/web/20200710174444/https://www.biorxiv.org/content/10.1101/2020.03.09.983817v1.full.pdf

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APOEϵ4 African local genomic ancestry (LA) confers less risk for Alzheimer disease (AD) relative to European LA (LA) carriers. Single nucleus RNA sequencing from AD-APOEϵ4/4 frontal cortex found European LA carriers have a 1.45-fold greater APOEϵ4 expression (p< 1.8 E10-313) and are associated with a unique A1 reactive astrocyte cluster. This suggests a potential mechanism for the increased risk for AD seen in European LA carriers of APOEϵ4.
doi:10.1101/2020.03.09.983817 fatcat:m3gno4rfy5ahvpsyja42goc6ha
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Anthony J Griswold, Katrina Celis, Parker Bussies, Farid Rajabli, Patrice Whitehead, Kara Hamilton-Nelson, Gary W Beecham, Derek M Dykxhoorn, Karen Nuytemans, Liyong Wang, Olivia K Gardner, Daniel Dorfsman, Eileen H Bigio, Marek-Marsel Mesulam, Sandra Weintraub, Changiz Geula, Marla Gearing, Elisa Martinez-McGrath, Clifton L Dalgard, William K Scott, Jonathan L Haines, Margaret A Pericak-Vance, Juan I Young, Jeffery M Vance. "Increased APOEϵ4 expression is associated with reactive A1 astrocytes and the difference in Alzheimer Disease risk from diverse ancestral backgrounds." bioRxiv (2020)