The role of poly(ADP-ribose) polymerase inhibitors in the treatment of endometrial cancer: a scoping review of the current literature

Samantha Ricci, Laura Parisi, Amy Knehans, Rebecca Phaeton, Joshua P Kesterson
2016 Clinical and Medical Investigations  
Objective: To describe, synthesize, and interpret literature on the role of poly (ADP-ribose) polyermase inhibitors in the treatment of endometrial cancer and to identify areas of interest for future reasearch. Design: Scoping review of the literature covering several study designs. Setting: Literature review. Methods: Systematic Searches of the electronic databases PubMed® (MEDLINE®), Cochrane Library®, CINAHL®, and Web of Science™ were performed, as well as web-based searches
more » ... ov, Canadian Clinical Trials & Cancer Trials, Australian Clinical Trials, WHO ICTRP, NIH Reporter, the CDC, and Google Scholar) for additional material, such as reports commissioned by government as well as non-governmental agencies. Literature was identified and organized into categories then synthesized to form conclusions and identify knowledge gaps. Results: 96 records were identified after searching the literature and 69 records were subsequently reviewed. Conclusion: There is conflicting evidence regarding the utility of proposed biomarkers in predicting sensitivity of endometrial cancer to PARP inhibitor treatment. Current in vitro and in vivo studies suggest that PARP inhibitors may be effective in the treatment of certain subsets of endometrial cancer, but further research is warranted.
doi:10.15761/cmi.1000102 fatcat:ccpkbmononbtvomolfwjqgm644