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Formulation of sustained release dosage form of simvastatin and ezetimibe and analytical development by reversed phase high performance liquid chromatography (RP-HPLC)
Int. J. of Farmacia
The present investigation relates to a process of preparing sustained release dosage forms containing simvastatin and ezetimibe in co mbination and assay by RP-HPLC method develop ment and validation. Chro matographic separation was achieved on a Water's Xterra colu mn (250 x 4.6, 5 microns) using a mobile phase consisting of Potassium di hydrogen phosphate and methanol in the rat io of 70:30 at a flo w rate of 0.8 ml per minute. The detection was made at 236 n m. The retention time of ezetfatcat:hgiutvz4gjehzjijysmkiicuci