Revisiting the Concept of Stress in the Prognosis of Solid Tumors: A Role for Stress Granules Proteins?

Anaïs Aulas, Pascal Finetti, Shawn M. Lyons, François Bertucci, Daniel Birnbaum, Claire Acquaviva, Emilie Mamessier
2020 Cancers  
Cancer treatments are constantly evolving with new approaches to improve patient outcomes. Despite progresses, too many patients remain refractory to treatment due to either the development of resistance to therapeutic drugs and/or metastasis occurrence. Growing evidence suggests that these two barriers are due to transient survival mechanisms that are similar to those observed during stress response. We review the literature and current available open databases to study the potential role of
more » ... potential role of stress response and, most particularly, the involvement of Stress Granules (proteins) in cancer. We propose that Stress Granule proteins may have prognostic value for patients.
doi:10.3390/cancers12092470 pmid:32882814 fatcat:fd3jarzdkvchnevbjaogkzayjy