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Nabe: an energetic database of amino acid mutations in protein–nucleic acid binding interfaces
2021
Database: The Journal of Biological Databases and Curation
Protein–nucleic acid complexes play essential roles in regulating transcription, translation, DNA replication, repair and recombination, RNA processing and translocation. Site-directed mutagenesis has been extremely useful in understanding the principles of protein–DNA and protein–RNA interactions, and experimentally determined mutagenesis data are prerequisites for designing effective algorithms for predicting the binding affinity change upon mutation. However, a vital challenge in this area
doi:10.1093/database/baab050
pmid:34389843
pmcid:PMC8363842
fatcat:jmehewyvjzelni2eajesp422zy