In this paper we initiate the study of multi-flavor Galileon theories using the methods of scattering amplitudes. We explore this topic from different perspectives and extend the techniques employed so far mainly in the single-flavor case. This includes soft theorems, generalized soft theorems with non-trivial right-hand side, Galileon dualities, soft bootstrap and bonus relations. We demonstrate new properties on two examples, the multi-flavor U(N) Galileon and the three-flavor U(2)/U(1) Galileon.