Blood potassium level associated with recovery of post-operative gastrointestinal motility during continuous renal replacement therapy in critically ill patient undergoing open abdominal surgery [post]

P Yang, Xin-Er Yao, Jing-Juan Yang, Yu Cui, Xia-Bing Lang, BS Wu, BS Wu, P Zhang, BS Yuan, Jiang-Hua Chen
2018 unpublished
Background: The purpose of the present study was to explore the potential therapeutic goal of blood potassium level beneficial to the post-operative recovery of gastrointestinal motility during continuous renal replacement therapy (CRRT) in critically ill patient undergoing open abdominal surgery. Methods: 538 critically ill patients after open abdominal surgery and receiving CRRT were retrospectively recruited as the study cohort. Demographic and clinical data including plasma potassium levels
more » ... were recorded along with evaluation of post-operative gastrointestinal motility. The median of first gastrointestinal motility recovery time was 4 days of the present study cohort, and we used gastrointestinal motility recovery during 4-day period and un-recovery at 4 days after the completion of surgery as the primary endpoints. Results: The received operating characteristic (ROC) curve analysis demonstrated that the post-operative blood potassium level during CRRT was significantly associated with the recovery of gastrointestinal motility (AUC = 0.72, p<0.001), and plasma potassium concentration at the cut-off point of the ROC curve was 4.00 mmol/L. Kaplan–Meier analysis indicated that compared with the patients with insufficient blood potassium level (plasma potassium concentration < 4.00mmol/L), those with sufficient level (plasma potassium concentration ≥4.00mmol/L) had higher rate of 4-day post-operative recovery of gastrointestinal motility (p<0.001). Logistic regression analysis indicated that the post-operative blood potassium level was independently associated with the recovery of gastrointestinal motility, patients with a sufficient blood potassium level conferred an increase in the rate of 4-day post-operative recovery of gastrointestinal motility (OR= 4.36, 95% CI 2.92-6.52, p<0.001). Conclusions: Our data indicated that keeping the blood potassium concentration at a relative high level of the regular blood potassium range during CRRT, would be beneficial to post-operative recovery of gastrointestinal motility, and eventually implied the potential therapeutic goal of blood potassium level for the recovery of post-operative gastrointestinal motility during CRRT in critically ill patient undergoing open abdominal surgery.
doi:10.21203/rs.1.12/v1 fatcat:ooo5avzdmjdldez3nelxuoyfgi