A comparative quantitative morphometric study of cell apoptosis in synovial membranes in psoriatic, reactive and rheumatoid arthritis

A Ceponis, J Hietanen, M Tamulaitiene, G Partsch, H Pätiälä, Y T Konttinen
1999 Rheumatology  
Objectives. Inflammatory arthritides/synovitides such as psoriatic (PsA), reactive (ReA) and rheumatoid (RA) arthritis share numerous immunopathological features, but develop different patterns of joint involvement. To investigate whether distinctive cell apoptosis may play a role in this context, we have assessed synovial cell apoptosis in situ in PsA and ReA, and compared it with RA and 'non-inflammatory' controls. Methods. TdT-mediated dUTP nick end-labelling ( TUNEL) of DNA breaks
more » ... ed immunoperoxidase staining for CD68 or LCA as the specific cell markers.
doi:10.1093/rheumatology/38.5.431 pmid:10371281 fatcat:da7i3qzo7je6zd2pcsq7vf2z5u