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Background In patients with presumed primary CNS lymphoma (PCNSL) a systemic manifestation is found only in a small minority. Although bone marrow biopsy (BMB) is recommended for staging, its diagnostic value is unclear. Methods A retrospective analysis of 392 patients with presumed PCNSL from three university hospitals and 33 patients with secondary CNS lymphoma (SCNSL) and initial CNS involvement from a multicentre Germany-wide prospective registry was performed. Results A BMB was performeddoi:10.1093/neuonc/noab109 pmid:33984138 pmcid:PMC8643483 fatcat:tg2qrmd6vjh5xav4hzntobo4vu