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Biological Evaluation of 2-Aryl-2-fluoropropionic Acids as Possible Platforms for New Medicinal Agents
2005
Chemical and pharmaceutical bulletin
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We investigated the cyclooxygenase (COX) inhibitory and anticancer activities of 2-aryl-2-fluoropropionic acids 1a-e. These fluorinated compounds showed lower inhibitory activity toward COX-1 than the corresponding non-fluorinated compounds 2a-e with retained inhibitory activity against COX-2 resulting in modification of the balance of COX-1/COX-2 inhibitions, and they showed little anticancer activity. Interesting differences of the activities between (S)-and (R)-enantiomers were observed in some cases.
doi:10.1248/cpb.53.1062
pmid:16079551
fatcat:ahe7nxuxurbkpgrwh64dkrqx5q