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The modulation of fragile X behaviors by the muscarinic M4 antagonist, tropicamide
2011
Behavioral Neuroscience
Muscarinic acetylcholine receptors (mAChR) are G-protein coupled receptors (M1-M5), grouped together into two functional classes, based on their G protein interaction. Although ubiquitously expressed in the CNS, the M4 protein shows highest expression in the neostriatum, cortex, and hippocampus. Electrophysiological and biochemical studies have provided evidence for overactive mAChR signaling in the fragile X knock-out (Fmr1KO) mouse model, and this has been hypothesized to contribute to the
doi:10.1037/a0025202
pmid:21942438
pmcid:PMC3183989
fatcat:dewzjn6q4bgndomhevstnlcdlu