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Objectives: To identify and validate a biomarker panel by serum metabolic profiling for improvement of PCa diagnosis. Materials and Methods: Totally, 134 individuals were included in this study. Among them, 39 PCa patients and 45 control patients (negative prostate biopsy) were involved in the discovery phase and 50 healthy controls were enrolled for validation phase of metabolomics study. LC-MS Analysis was used for the identification of the serum metabolites of patients. Results: Logisticsdoi:10.21203/rs.3.rs-151526/v1 fatcat:mxvtvandtralpig7yyefru7rja