2022-RA-1364-ESGO Implementation of molecular classification in endometrial cancer and its impact on indication of adjuvant therapy

Laura Cárdenas Puiggrós, Pedro Alberto Corzo Orantos, Isabel Núñez Márquez, Anna Taltavull Pons, Anna Taltavull Pons, Cristina Meléndez Muñoz, Anna Carbó Bagué, Hugo Javier Rosales González, Eduard Sala Hernández, Elena Álvarez Castaño
2022 Endometrial cancer   unpublished
isolated and diffuse lymphovascular space invasion [(LVSI) OR 2.51, 95%CI 1. OR 3.27, p<0.001, respectively), cervical stromal invasion [(CSI) OR 4.26, 95%CI 3.00-6.05; p<0.001], and instable mismatch repair (iMMR) phenotype (OR 1.96, 95%CI 1.24-3.08; p=0.004) found as independent predictors (Table ) . Remarkably, adnexal involvement in EC further revealed an independent negative predictive factor of RFS (HR 3.20, 95%CI 1.66-6.18; p=0.001), whilst only a suggestive negative role emerged on OS
more » ... R 1.73, 95%CI 0.93-3.24; p=0.086). Consistently, 5-years RFS and OS were shorter among women with adnexal involvement compared with those without (63.3 vs. 87.5%, and 68.6 vs. 92.9%, p<0.001, respectively). Conclusion Main predictors of adnexal involvement in EC are iMMR phenotype, MI, isolated and diffuse LVSI, and CSI. Although adnexal involvement incidence is low, this may be associated with higher recurrence risk.
doi:10.1136/ijgc-2022-esgo.314 fatcat:d7x6nd4ei5hchijpistgdz6yiq