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Decision letter: IRAK1-dependent Regnase-1-14-3-3 complex formation controls Regnase-1-mediated mRNA decay
Regnase-1 is an endoribonuclease crucial for controlling inflammation by degrading mRNAs encoding cytokines and inflammatory mediators in mammals. However, it is unclear how Regnase-1-mediated mRNA decay is controlled in interleukin (IL)-1b-or Toll-like receptor (TLR) ligand-stimulated cells. Here, by analyzing the Regnase-1 interactome, we found that IL-1b or TLR stimulus dynamically induced the formation of Regnase-1-b-transducin repeat-containing protein (bTRCP) complex. Importantly, we alsodoi:10.7554/elife.71966.sa1 fatcat:x73b6iqmafd5relsmlitcfwou4