Pituitary Adenylate Cyclase-Activating Polypeptide1 (PACAP) [chapter]

Encyclopedia of Neuroscience  
Pituitary adenylate cyclase activating peptide (PACAP) is found in human trigeminocervical complex and can trigger migraine. PACAP levels were measured using a sensitive radioimmunoassay. Stimulation of the superior sagittal sinus (SSS) in cat elevated PACAP levels in cranial blood. Patients with moderate or severe migraine headache had elevated PACAP in the external jugular vein during headache (n = 15), that was reduced 1 h after treatment with sumatriptan 6 mg (n = 11), and further reduced
more » ... terictally (n = 9). The data suggest PA-CAP, or its receptors, are a promising target for migraine therapeutics.
doi:10.1007/978-3-540-29678-2_4601 fatcat:cylcttlihve65g5ivh7hooxaxi