ON THE OBSERVABILITY AND STATE ESTIMATION IN A CLASS OF GENE-EXPRESSION SYSTEM

RICARDO AGUILAR-LOPEZ, JUAN L. MATA-MACHUCA
2018 Dynamic systems and applications  
The failure of available physical sensors for the online measurement of protein concentration in cells is a key problem to understanding the transition in bio-systems. In this paper, a new state observer has been designed to estimate three protein concentrations by using a gene-expression mathematical model. Interestingly, its only input is the concentration of one messenger RNA (mRNA). Similarly by differential-algebraic observability analysis is showed that the gene-expression model is indeed
more » ... observable. The observer convergence was demonstrated by analysing the estimation error dynamics. In silico experiments confirm the satisfactory performance of this new observer.
doi:10.12732/dsa.v27i3.5 fatcat:iqbtkwbp4zgihpyqvs5iq35zeu