Regulatory B Cells: Key Players in Hepatocellular Carcinoma Progression

Helal F Hetta
2016 Gastroenterology & Hepatology Open Access  
Recently, many reports explored new subsets of the immune cells as regulatory T cells (Tregs) and regulatory B cells (Bregs) which are linked to the tumor immune surveillance and suppress the immune system to promote cancer genesis and progression [2, 4] . Bregs are special subset of B cells found to be abundant in the tumor microenvironment and was a leading cause of progression of various cancers, including HCC. Breg induce progression of HCC by several signaling pathways [4, 5] . In this
more » ... 4, 5] . In this review, we Volume 5 Issue 2 -2016 Abstract Understanding these mechanisms may direct us to a novel therapeutic approach targeting Breg for treatment of HCC.
doi:10.15406/ghoa.2016.05.00136 fatcat:36izg264vndvfdw4l2iwmix7cy