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Carbohydrate Recognition Mechanism of the Mushroom Galectin ACG
Trends in glycoscience and glycotechnology
The fruiting body of the edible mushroom Agrocybe cylindracea contains a proto-type galectin named ACG, which shows affinity to a wide range of β-galactosides. Unlike other galectins, it also binds to disaccharides (GalNAcα1-3Gal/GalNAc) found in blood group A and Forssman epitopes. Structurally, ACG lacks an evolutionarily conserved Asn located on the S4 strand (Ala64) but is compensated for by Asn46, which is located on the extended loop region unique to this galectin. A recent site-directeddoi:10.4052/tigg.1736.1se fatcat:emxhmajqmfa27ld7ukx2z33qom