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Drug Discovery Today
With more than 10 years of practical experience and theoretical analysis, fragment-based drug discovery (FBDD) has entered the mainstream of the pharmaceutical and biotech industries. An array of biophysical techniques has been used to detect the weak interaction between a fragment and the target. Each technique presents its own requirements regarding the fragment collection and the target; therefore, in order to optimize the potential of FBDD, the nature of the target should be a drivingdoi:10.1016/j.drudis.2007.08.005 pmid:18061882 fatcat:y6hf5zo46fb5bnptlcbwprab2q