Transcutaneous fluorescence spectroscopy as a tool for non-invasive monitoring of gut function: first clinical experiences

James Maurice, Aaron M. Lett, Charlotte Skinner, Alexandra Lim, Matthew Richardson, Ajesh Painadath Thomas, Peter A. Summers, Khushi Vyas, Abdul Wadood Tadbier, Ramon Vilar, Marina K. Kuimova, Serge Miodragovic (+8 others)
2020 Scientific Reports  
Gastro-intestinal function plays a vital role in conditions ranging from inflammatory bowel disease and HIV through to sepsis and malnutrition. However, the techniques that are currently used to assess gut function are either highly invasive or unreliable. Here we present an alternative, non-invasive sensing modality for assessment of gut function based on fluorescence spectroscopy. In this approach, patients receive an oral dose of a fluorescent contrast agent and a fibre-optic probe is used
more » ... make fluorescence measurements through the skin. This provides a readout of the degree to which fluorescent dyes have permeated from the gut into the blood stream. We present preliminary results from our first measurements in human volunteers demonstrating the potential of the technique for non-invasive monitoring of multiple aspects of gastro-intestinal health.
doi:10.1038/s41598-020-73149-2 pmid:32999336 fatcat:cptpjtjozzaqjpsdykdqmnpd3m