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Mitochondria Are Direct Targets of the Lipoxygenase Inhibitor MK886
Journal of Biological Chemistry
We have investigated the mitochondrial and cellular effects of the lipoxygenase inhibitor MK886. Low concentrations (1 M) of MK886 selectively sensitized the permeability transition pore (PTP) to opening, whereas higher concentrations of MK886 (10 M) caused depolarization through combination of an ionophoretic effect with inhibition of respiration. MK886 killed prostate cancer PC3 cells only at the higher, toxic concentration (10 M), whereas the lower concentration (1 M) had no major effect ondoi:10.1074/jbc.m204450200 pmid:12080072 fatcat:cugax5brvbaanahgtc7lfz5ceq