Clinical findings about the adverse effects of the use of antiretroviral drugs in the oral cavity of people with HIV / AIDS began to be found. A case regarding the side effects of the use of antiretroviral drugs is the discovery of oral cavity lesions in the form of whitish plaque on the lips and right buccal mucosa that has occurred more than one month accompanied by complaints of taste disorders, xerostomia, and a burning feeling in the mucosa of patients using Nevirapine, Zidovudine and

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... udine. This study was to analyze the relationship of anti-retroviral treatment in HIV AIDS sufferers to caries predictors, and caries severity, and analyze the relationship between the duration of antiretroviral treatment to caries predictors and caries severity. This study used an observational method with cross sectional or cross sectional design by conducting direct observations, on 100 samples of HIV / AIDS sufferers using anti-retroviral drugs at the Yayasan Peduli Kelompok Dukungan Sebaya (YPKDS) Makassar held in October 2019. Data were analyzed with chi square test.