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Nephrotic syndrome is associated with increased plasma K+ concentration, intestinal K+ losses and attenuated urinary K+ excretion - studies in rats and humans
2019
AJP - Renal Physiology
The present study tested the hypotheses that nephrotic syndrome (NS) leads to renal K+ loss due to augmented ENaC activity followed by down-regulation of renal K+- secretory pathways by suppressed aldosterone. The hypotheses were addressed by determining K+-balance and kidney abundance of K+- and Na+ transporter proteins in puromycin aminonucleoside (PAN)-induced rat nephrosis. Effect of amiloride and angiotensin II-AT1 and mineralocorticoid receptor (MR) antagonists were tested.
doi:10.1152/ajprenal.00179.2019
pmid:31566427
fatcat:fcv22kysxrcdrkvzaqlu7kdbjm