Colorectal cancer (CRC) represents one of the leading causes of morbidity and cancer-related mortality in the world. While the etiology of CRC is believed to arise from genetic mutations, alterations in the gut microbiota composition also influence cancer incidence and progression. This review focuses on how gut microbiota and their relationship with the innate immune system link inflammation to genotoxicity and carcinogenesis. Plasticity represents a fundamental aspect of stem cell dynamics

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... hierarchy. The epigenetic similarities between ISCs and their crypt progenitor cells allow them to respond to niche stimuli and shift between different functional states, including quiescence and proliferation www.annualreviews.org • The Gut Microbiome and Colorectal Cancer 231 Annu. Rev. Cancer Biol. 2018.2:229-249. Downloaded from www.annualreviews.org Access provided by 207.241.225.236 on 05/07/20. For personal use only. Annu. Rev. Cancer Biol. 2018.2:229-249. Downloaded from www.annualreviews.org Access provided by 207.241.225.236 on 05/07/20. For personal use only.