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Colorectal cancer (CRC) represents one of the leading causes of morbidity and cancer-related mortality in the world. While the etiology of CRC is believed to arise from genetic mutations, alterations in the gut microbiota composition also influence cancer incidence and progression. This review focuses on how gut microbiota and their relationship with the innate immune system link inflammation to genotoxicity and carcinogenesis. Plasticity represents a fundamental aspect of stem cell dynamicsdoi:10.1146/annurev-cancerbio-030617-050240 fatcat:n5i4zfyurnffxlen2r6m7orhza