Optical clearing agents can improve tissue optical transmittance by reducing the diffuse reflection. The reflection on in vivo human skin before and after applying anhydrous glycerol and 30 to 50% liquid paraffin glycerol mixed solution are investigated in this paper. From their visible and near-infrared reflection spectroscopy, all of their diffuse reflections are reduced after applying the agents. It is found that the three mixed solutions show stronger effect than that of anhydrous glycerol.

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... These results further prove liquid paraffin can enhance the percutaneous penetration of glycerol and take synergistically optical clearing effect with glycerol over visible and near-infrared wave bands. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.