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Application of rat medium-term bioassays for detecting carcinogenic and modifying potentials of endocrine active substances
2003
Pure and Applied Chemistry
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Two in vivo bioassay methods, a rat medium-term liver bioassay and a rat multiorgan bioassay, can be used for detecting carcinogenic or modifying potentials of endocrine active substances (EASs) on endocrine disruption (ED). The first bioassay, the rat mediumterm liver bioassay, is fundamentally based on the two-step hypothesis of liver carcinogenesis; initiation with diethylnitrosamine (DEN, 200 mg/kg b.w., ip) is followed by test chemical administrations during the second stage, in
doi:10.1351/pac200375112491
fatcat:2zhi3mbsmvagli4lragmco2icm