A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL.
The file type is
Increased expression of SAMHD1 in a subset of HIV-1 elite controllers
Journal of Antimicrobial Chemotherapy
Objectives: SAMHD1 and the CDKN1A (p21) cyclin-dependent kinase inhibitor have been postulated to mediate HIV-1 restriction in CD4+ cells. We have shown that p21 affects HIV replication through its effect on SAMHD1. Thus, we aimed at evaluating the expression of SAMHD1 and p21 in different HIV+ phenotypic groups. Patients and methods: We evaluated SAMHD1 and CDKN1A mRNA expression in CD4+ T cells from HIV+ individuals including elite controllers (n¼ 12), individuals who control HIV without thedoi:10.1093/jac/dku276 pmid:25063780 fatcat:rpq3cx3cizep7ixwjhgcjvpcjm