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We investigated the role of fibrin in the sequestration of neutrophils hi lungs challenged with microembolism. Lungs of chronically prepared awake sheep were imaged after Infusion of '"In-neutrophils and ul I-fibrinogen. Thrombin (80 units/kg) was administered to induce fibrin sequestration hi the lung. One group received tranexamic add (4 mg/kg i.v.) to inhibit fibrinolysis, and the control group received a saline infusion. Thrombin infusion increased both u 'I-fibrinogen and "'In-neutrophilsdoi:10.1161/01.res.63.4.735 pmid:3168176 fatcat:sq3mohtuabdthbjobm27cxtzu4