Monitoring photodynamic therapy with photoacoustic microscopy

Peng Shao, David W. Chapman, Ronald B. Moore, Roger J. Zemp
2015 Journal of Biomedical Optics  
We present our work on examining the feasibility of monitoring photodynamic therapy (PDT)-induced vasculature change with acoustic-resolution photoacoustic microscopy (PAM). Verteporfin, an FDA-approved photosensitizer for clinical PDT, was utilized. With a 60-μm-resolution PAM system, we demonstrated the capability of PAM to monitor PDT-induced vasculature variations in a chick chorioallantoic membrane model with topical application and in a rat ear with intravenous injection of the
more » ... izer. We also showed oxygen saturation change in target blood vessels due to PDT. Success of the present approach may potentially lead to the application of PAM imaging in evaluating PDT efficacy, guiding treatment, and predicting responders from nonresponders.
doi:10.1117/1.jbo.20.10.106012 pmid:26509414 fatcat:niyvdgbsgbcs7aebgyl2yw733e