Effects of neonicotinoid and organophosphorus insecticides on macrophage functions

Kanako Sasou, Miyoko Matsushima, Nanako Ogasawara, Tomoko Ohdachi, Kazuko Atsumi, Kyohka Tanaka, Tomoshi Sugiyama, Jun Ueyama, Naozumi Hashimoto, Tsutomu Kawabe
2018 Proceedings for Annual Meeting of The Japanese Pharmacological Society  
Neonicotinoid insecticides and organophosphorus (OP) insecticides that act on the cholinergic nervous system of insects, are major insecticides used in agriculture throughout the world. The effects of neonicotinoid insecticides and OP insecticides cause overstimulation and desensitization in the nervous system by interacting with the nicotinic acetylcholine receptors (nAChRs) and inhibiting acetylcholine-esterase, respectively. The immunotoxicity of OP insecticides to human has been reported,
more » ... cluding exacerbation of inflammation and asthma, and we have reported that diazinon, one of OP insecticides, modulated macrophage functions. Although neonicotinoid insecticides are thought to be relatively low toxic for human compared to OP insecticides due to the low affinity of mammalian nAChRs, less is known about the exact effects of neonicotinoid insecticides. In this study, we investigated the effects of neonicotinoid insecticides and OP insecticides on macrophage functions, such as cytokine production, the levels of cell-surface molecule expression, and phagocytosis in RAW264.7 cells. We also investigated the induction of autophagy by neonicotinoid insecticides and OP insecticides. Poster session WCP2018
doi:10.1254/jpssuppl.wcp2018.0_po3-13-24 fatcat:5yalfglxtfef5mmlnc7kjxukhe