This study shows the effect of wastewater of El-Sail Drain on the strength of Oreochromis niloticus gathered from two destinations of River Nile at Aswan Governorate. The physicochemical parameters of water such as pH, electric conductivity, complete broke down solids, disintegrated oxygen, organic and concoction oxygen requests; nitrite, nitrate and alkali were resolved. Substantial metals (Cu, Pb, Cd and Ni) fixations in water and fish tissues were recognized. The microbiological,

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... cal and neurotic states of fish were likewise researched. Higher estimations of pH, EC, BOD and COD were recognized in site II than from site I. As opposed to DO, nitrite, nitrate and smelling salts which were lower in site II. Substantial metals focuses in water of both sites, particularly Ni, Pb and Cd surpassed as far as possible and its abundance followed the order: Pb>Ni>Cd>Cu. Total bacterial count, all out coliform, Salmonella sp., Shigella sp. and E. coli were recognized in higher numbers in water tests from site II. Additionally, the fish got from that site revealed higher bacterial and parasitic contamination. The bioaccumulation of Ni and Pb surpassed the most extreme allowable limit; in any case, Cu and Cd focuses were underneath as far as possible in various tissues. The bioaccumulation variable of Cu demonstrated its most noteworthy worth in liver. The histopathological injuries were more prominent in fish gathered from site II. Thus, expending fish got from the considered locales around El-sail drain disposal point speaks to serious risk on human health.