How Long Will My Mouse Live? Machine Learning Approaches for Prediction of Mouse Life Span

W. R. Swindell, J. M. Harper, R. A. Miller
2008 The journals of gerontology. Series A, Biological sciences and medical sciences  
Prediction of individual lifespan based upon characteristics evaluated at middle-age represents a challenging objective for aging research. In this study, we used machine learning algorithms to construct models that predict lifespan in a stock of genetically heterogeneous mice. Lifespanprediction accuracy of 22 algorithms was evaluated using a cross-validation approach, in which models were trained and tested with distinct subsets of data. Using a combination of body weight and T-cell subset
more » ... sures evaluated before two years of age, we show that the lifespan quartile to which an individual mouse belongs can be predicted with an accuracy of 35.3% (± 0.10%). This result provides a new benchmark for the development of lifespan-predictive models, but improvement can be expected through identification of new predictor variables and development of computational approaches. Future work in this direction can provide tools for aging research and will shed light on associations between phenotypic traits and longevity.
doi:10.1093/gerona/63.9.895 pmid:18840793 pmcid:PMC2693389 fatcat:zpcylalfqze3lmi2f5gp4zhfsy