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Amino acid residues Ala283 and His421 in the RNA-dependent RNA polymerase of porcine reproductive and respiratory syndrome virus play important roles in viral ribavirin sensitivity and quasispecies diversity
2016
Journal of General Virology
The quasispecies diversity of RNA viruses is mainly determined by the fidelity of RNAdependent RNA polymerase (RdRp) during viral RNA replication. Certain amino acid residues play an important role in determining the fidelity, and such residues can be substituted with other amino acids to produce virus strains with higher fidelity. In this study, two amino acid substitutions (A283T and H421Y) in the RdRp of porcine reproductive and respiratory syndrome virus (PRRSV) were identified under the
doi:10.1099/jgv.0.000316
pmid:26487085
fatcat:j46s224auvek3purhu2eq2uvwq