Drug delivery without nanoparticle uptake: delivery by a kiss-and-run mechanism on the cell membrane

Daniel Hofmann, Claudia Messerschmidt, Markus B. Bannwarth, Katharina Landfester, Volker Mailänder
2014 Chemical Communications  
Nearly all concepts of nanocarriers as drug delivery devices rely on intracellular uptake. Instead, we demonstrate an alternative concept for rapid and specific delivery of cargo by nanoparticles to TIP47+/ ADRP+ lipid droplets. The model can serve as a novel strategy for the non-invasive delivery of drugs by releasing hydrophobic cargo, in our case a model dye, through a kiss-and-run mechanism between nanoparticles and the cell membrane.
doi:10.1039/c3cc48130a pmid:24346146 fatcat:ssc4hq5chrarjo55sruoisbyje