2) RESULTS a. Germ line to soma transition is an orderly, multistep process. b. Translational repression of Cyclin E prevents precocious mitosis and embryonic gene activation during C.elegans meiosis. i. Introduction to the published manuscript. ii. Copy of the published manuscript. c. Promoting proliferation over transdifferentiation -GLP-1/Notch the second driving force in the gld-1 tumor. d. Model: i. Preventing tumor formation and germ line to soma transition -a matter of translational

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... ol of the cell cycle and differentiation factors. 3) EXTENDED DISCUSSION a. How could ectopic activation of CYE-1/CDK-2 promote re-entry into mitosis? b. How could ectopic CYE-1/CDK-2 activity promote embryonic gene activation (EGA)? c. Do GLD-1 and the related quaking proteins have a conserved function in regulating development through balancing cell cycle and differentiation factors? i. GLD-1 belongs to the STAR (signal transduction and activation of RNA) family of RNA-binding proteins. ii. GLD-1 belongs to the Quaking proteins, a STAR subfamily. iii. GLD-1, a translational regulator coordinating germ cell development in C.elegans. iv. How (held out wings) the Drosophila quaking homolog. v. The mouse Quaking proteins vi. Different mechanisms of RNA regulation, but balancing cell cycle and differentiation factors seems to be a conserved function of Quaking homologs. vii. Quaking's function as tumor suppressor. viii. Balancing cell cycle and differentiation factors is a central function to regulate development.