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A critical role for touch neurons in a skin-brain pathway for stress resilience
[article]
2022
bioRxiv
pre-print
AbstractSocial touch can act as a stress buffer, reducing behavioral and physiological responses to stressful scenarios. However, skin-brain touch pathways that promote stress resilience remain unknown. Here, we show that mice with an early life genetic ablation of Mrgprb4-lineage touch neurons display stress vulnerability behaviors in adulthood. Chemogenetic activation of these touch neurons reduced corticosterone levels under mild acute stress conditions. In addition, whole-brain c-Fos
doi:10.1101/2022.05.23.493062
fatcat:if5upt2m5jfnnphahddzb4frgu