Evaluation of serum ischemia-modified albumin levels in pregnant women with and without gestational diabetes mellitus

Shao-gang Ma, Wei-nan Yu, Yue Jin, Bing Hong, Wen Hu
2012 Gynecological Endocrinology  
Gestational diabetes mellitus (GDM), a glucose intolerance state during pregnancy is a strong predictor of post-partum prediabetes and one of the risk factors for overt type 2 diabetes (T 2 DM). Magnesium a trace element influences the cell's response to insulin and decreased levels of magnesium are related to insulin resistance and T 2 DM. Several literatures are available on effects of magnesium on T 2 DM with dearth in research regarding the impact of magnesium on GDM. In this backdrop our
more » ... this backdrop our present study was designed to determine serum magnesium level in women with and without GDM. A cross sectional case control study was conducted at Adichunchanagiri Institute of Medical Sciences and Hospital. The total numbers of subjects were 90, divided into two groups, Group I-45 pregnant women with Gestational diabetes mellitus as cases, Group II-45 pregnant women without GDM as controls. Blood samples were drawn under aseptic precautions from study subjects. Serum magnesium levels were determined by commercially available Calmagite kit method. The mean serum magnesium level was found to be significantly lower in group I subjects when compared to group II subjects with the p value <0.0001. To conclude, results of our study demonstrated that hypomagnesaemia an underlying factor in determining disrupted glucose metabolism in pregnant women and magnesium supplementation might help patients with GDM to control their metabolic profile and pregnancy outcomes.
doi:10.3109/09513590.2012.683069 pmid:22571721 fatcat:uchlby65qrbvbn7l4bvt7kus5e