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Clinical feasibility study of combined opto-acoustic and ultrasonic imaging modality providing coregistered functional and anatomical maps of breast tumors

Jason Zalev, Bryan Clingman, Remie J. Smith, Don Herzog, Tom Miller, A. Thomas Stavros, Sergey Ermilov, André Conjusteau, Dmitri Tsyboulski, Alexander A. Oraevsky, Kenneth Kist, N. C. Dornbluth (+3 others)
2013 Photons Plus Ultrasound: Imaging and Sensing 2013  

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Two-dimensional optoacoustic imaging with a hand-held probe operated in backward mode is being developed for diagnostic imaging of breast cancer to evaluate the feasibility of a dual-modality optoacoustic plus ultrasonic system that maps functional information of anatomical tissue structures with ultrasonic resolution. Tissue is illuminated at 757nm and 1064nm for optical contrast between hypoxic blood of breast carcinomas and normally oxygenated blood in benign masses. The system is optimized
more » ... nd calibrated in phantoms for a pilot clinical study of patients with breast masses suspected for malignancy. Capability of the non-invasive system to improve detection and diagnosis of breast tumors is discussed.
doi:10.1117/12.2009112 fatcat:tv6ethw7yfhcvgcxecb7ofkliy
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Jason Zalev, Bryan Clingman, Remie J. Smith, Don Herzog, Tom Miller, A. Thomas Stavros, Sergey Ermilov, André Conjusteau, Dmitri Tsyboulski, Alexander A. Oraevsky, Kenneth Kist, N. C. Dornbluth, Pamela Otto, Alexander A. Oraevsky, Lihong V. Wang. "Clinical feasibility study of combined opto-acoustic and ultrasonic imaging modality providing coregistered functional and anatomical maps of breast tumors." Photons Plus Ultrasound: Imaging and Sensing 2013 (2013)