End-stage renal disease (ESRD) disease is a public health problem worldwide that is highly associated with medical, social and psychological disorders particularly in those treated with Hemodialysis. It leads to loss in mobility, exercise capacity, and self-assessed physical function, and is further associated with reduced ability to work and function in daily life. Objectives: This study was aimed to assess the quality of life (QOL) among Hemodialysis patients admitted at the National

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... e National Methodology: A cross-sectional prospective study was conducted at Hemodialysis units of National Ribat University Hospital and Ibn Sina Specialized Hospital in 120 patients undergoing regular Hemodialysis for more than six months. The WHO quality of life questionnaire was used. Verbal and written consent was taken from any patient after explaining the purpose of the study. Statistical analysis was performed using SPSS version 25.0. Results: One hundred-twenty patients were enrolled which included forty males (66.7%) and twenty (33.3%) females. The assessment of quality of life shows only 10% have good QOL, 46.6% have moderate QOL, 40% have poor QOL and 3.3% have very poor QOL. Conclusion: Generally person with ESRD are more likely to have reduced quality of life and poor overall health in compared with subjects with normal renal function. This findings suggest that ESRD maintained on prolonged Hemodialysis is associated with reduced relatively decreased QOL and long term bad outcomes affecting subject's overall aspects of health.