Myocardial viability assessment by endocardial electroanatomic mapping: comparison with metabolic imaging and functional recovery after coronary revascularization

Karl-Christian Koch, Juergen vom Dahl, Monika Wenderdel, Bernd Nowak, Wolfgang M Schaefer, Alexander Sasse, Christoph Stellbrink, Udalrich Buell, Peter Hanrath
2001 Journal of the American College of Cardiology  
OBJECTIVES The objective of this study was to compare electroanatomic mapping for the assessment of myocardial viability with nuclear metabolic imaging using positron emission computed tomography (PET) and with data on functional recovery after successful myocardial revascularization. BACKGROUND Animal experiments and first clinical studies suggested that electroanatomic endocardial mapping identifies the presence and absence of myocardial viability. METHODS Forty-six patients with prior (Ն2
more » ... ks) myocardial infarction underwent fluorine-18 fluorodeoxyglucose (FDG) PET and Tc-99m sestamibi single-photon emission computed tomography (SPECT) before mapping and percutaneous coronary revascularization. The left ventricular endocardium was mapped and divided into 12 regions, which were assigned to corresponding nuclear regions. Functional recovery using the centerline method was assessed in 25 patients with a follow-up angiography. RESULTS Regional unipolar electrogram amplitude was 11.0 mV Ϯ 3.6 mV in regions with normal perfusion, 9.0 mV Ϯ 2.8 mV in regions with reduced perfusion and preserved FDG-uptake and 6.5 mV Ϯ 2.6 mV in scar regions (p Ͻ 0.001 for all comparisons). At a threshold amplitude of 7.5 mV, the sensitivity and specificity for detecting viable (by PET/SPECT) myocardium were 77% and 75%, respectively. In infarct areas with electrogram amplitudes Ͼ7.5 mV, improvement of regional wall motion (RWM) from Ϫ2.4 SD/chord Ϯ 1.0 SD/chord to Ϫ1.5 SD/chord Ϯ 1.1 SD/chord (p Ͻ 0.01) was observed, whereas, in infarct areas with amplitudes Ͻ7.5 mV, RWM remained unchanged at follow-up (Ϫ2.3 SD/ chord Ϯ 0.7 SD/chord to Ϫ2.4 SD/chord Ϯ 0.7 SD/chord). CONCLUSIONS These data suggest that the regional unipolar electrogram amplitude is a marker for myocardial viability and that electroanatomic mapping can be used for viability assessment in the catheterization laboratory. (J Am Coll Cardiol 2001;38:91-8)
doi:10.1016/s0735-1097(01)01314-6 pmid:11451302 fatcat:ckymio6lvfhdxk3pyopreyk7py