Chronic kidney disease is defined by reduced estimated glomerular filtration rate (reduced eGFR) or by microalbuminuria (MA). Concordance between reduced eGFR and MA and associated cardiovascular disease (CVD) and all-cause mortality according to these definitions is uncertain. Methods: Participants (n=2966 [52.6% were women], mean age, 59 years) were drawn from the Framingham Offspring Cohort. Participants were classified into 4 groups based on the presence or absence of reduced eGFR (eGFRϽ59

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... L/min/1.73 m 2 in women, Ͻ64 mL/min/ 1.73 m 2 in men or MA (spot urinary albumin to creatinine ratio of at least 30 mg/g). Cox proportional hazard models were used to determine the combined risk of CVD events and all-cause mortality for each group. Results: Of the participants, 9.9% (n=295) had reduced eGFR, and 12.2% (n=362) had MA. Among those with reduced eGFR, 28% had MA. Those with reduced eGFR and