Cross-Classification of Microalbuminuria and Reduced Glomerular Filtration Rate

Meredith C. Foster, Shih-Jen Hwang, Martin G. Larson, Nisha I. Parikh, James B. Meigs, Ramachandran S. Vasan, Thomas J. Wang, Daniel Levy, Caroline S. Fox
2007 Archives of Internal Medicine  
Chronic kidney disease is defined by reduced estimated glomerular filtration rate (reduced eGFR) or by microalbuminuria (MA). Concordance between reduced eGFR and MA and associated cardiovascular disease (CVD) and all-cause mortality according to these definitions is uncertain. Methods: Participants (n=2966 [52.6% were women], mean age, 59 years) were drawn from the Framingham Offspring Cohort. Participants were classified into 4 groups based on the presence or absence of reduced eGFR (eGFRϽ59
more » ... L/min/1.73 m 2 in women, Ͻ64 mL/min/ 1.73 m 2 in men or MA (spot urinary albumin to creatinine ratio of at least 30 mg/g). Cox proportional hazard models were used to determine the combined risk of CVD events and all-cause mortality for each group. Results: Of the participants, 9.9% (n=295) had reduced eGFR, and 12.2% (n=362) had MA. Among those with reduced eGFR, 28% had MA. Those with reduced eGFR and
doi:10.1001/archinte.167.13.1386 pmid:17620532 fatcat:aybkawf7xjgclm3546llu2wcqu