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The receptor gp130 is utilized by cytokines including interleukin 6, leukemia inhibitory factor, oncostatin M, cilary neurotrophic factor and cardiotrophin. It is essential for myocardial development and haematopoiesis during embryogenesis, and its role as a shared signal transducer among different cytokines explains their overlapping biological functions. Although gp130 contains a cytokinebinding homology region (CHR) analogous to the extracellular growth hormone receptor, the complexes thatdoi:10.1093/protein/11.11.1093 pmid:9876932 fatcat:mv7bqifumra6xj5so34mok5lhy